東北大学大学院医学系研究科・医学部

STAFF

Professor

• Asano, NaokiProfessor. 浅野 直喜 教授

CONTACT

OUTLINE

Aging is one of the main risk factors for cancers. As Japan has become a super-aging society and the whole world is experiencing an increasingly aging population, unraveling the mechanism involved in aging-related carcinogenesis has become exceptionally crucial and is anticipated to lead to promising therapies targeting aging-related cancers. On the other hand, the aging of tissue stem cells within our bodies, referred to as stem cell aging, is deemed the main cause of aging. We aim to elucidate the mechanism of aging-related carcinogenesis in terms of stem cell aging.
Our division is an affiliated division established at the Miyagi Cancer Center Research Institute located in Natori City.

加齢・老化は種々の臓器において、発がんのリスク因子であることが報告されています。本邦は超高齢社会を迎え、世界的にも高齢化が進む中で、加齢・老化に伴う発がん機序の解明は喫緊の課題であり、将来的には治療に結びつくことが期待されます。一方、わたしたちの体内に存在する組織幹細胞の老化（幹細胞老化）が個体としての老化の主要な要因であると考えられています。わたしたちはこの幹細胞老化の観点から、老化に伴う発がん機序の解明を目指して研究を進めています。
当分野は宮城県立がんセンター研究所（名取市）に設置された連携講座です。

ARTICLE

Mochizuki M et al. CD271 mRNA/hnRNPA2B1 complex promotes proliferation and stemness in oral and head and neck squamous cell carcinoma. Cancer Sci. (online ahead of print) (2024)
URL：https://doi.org/10.1111/cas.16187

Fujimori H et al. FAXC interacts with ANXA2 and SRC in mitochondria and promotes tumorigenesis in cholangiocarcinoma. Cancer Sci. (online ahead of print) (2024)
URL：https://doi.org/10.1111/cas.16140

Asano N et al. Wnt signaling and aging of the gastrointestinal tract. (Review) Int J Mol Sci. 23(20):12210. (2022)
URL：https://doi.org/10.3390/ijms232012210

Fujii K et al. Establishment of a monoclonal antibody against glycosylated CD271 specific for cancer cells in immunohistochemistry. Cancer Sci. 113(8):2878-87. (2022)
URL：https://doi.org/10.1111/cas.15340

Tamai K et al. Cancer stem cells in intrahepatic cholangiocarcinoma; Their molecular basis, and therapeutic implications. (Review) Front Physiol. 12:824261. (2022)
URL：https://doi.org/10.3389/fphys.2021.824261